Jian-Hua Ding Selected Research

N- (1- methylethyl)- 1,1,2- trimethylpropylamine

9/2014	Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis.
4/2009	Iptakalim ameliorates MPP+-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoK(ATP) channels.
12/2007	Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.
6/2006	Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils.
5/2005	Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats.

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Jian-Hua Ding Research Topics

Disease

20	Parkinson Disease (Parkinson's Disease) 01/2021 - 05/2005
10	Neuroinflammatory Diseases 10/2019 - 12/2007
8	Breast Neoplasms (Breast Cancer) 01/2015 - 01/2009
6	Inflammation (Inflammations) 09/2018 - 01/2014
6	Colorectal Neoplasms (Colorectal Cancer) 01/2014 - 11/2007
5	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2018 - 05/2005
4	Stroke (Strokes) 01/2019 - 06/2006
3	Brain Diseases (Brain Disorder) 10/2019 - 08/2013
3	Ischemic Stroke 01/2019 - 09/2008
3	Neoplasms (Cancer) 05/2016 - 11/2007
2	Brain Ischemia (Cerebral Ischemia) 01/2019 - 06/2006
2	Rectal Neoplasms (Rectal Cancer) 01/2012 - 11/2007
2	Stomach Neoplasms (Stomach Cancer) 01/2010 - 04/2004
2	Substance-Related Disorders (Drug Abuse) 07/2009 - 04/2006
2	Colonic Neoplasms (Colon Cancer) 04/2008 - 11/2007
2	Ischemia 06/2006 - 05/2005
2	Catalepsy 06/2005 - 05/2005
1	Insulin Resistance 01/2019
1	Reperfusion Injury 01/2019
1	Dyskinesias (Dyskinesia) 01/2017
1	Synucleinopathies 12/2016
1	Ascites 05/2016
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016
1	Myopia 01/2015
1	Liver Diseases (Liver Disease) 04/2014
1	Type 2 Diabetes Mellitus (MODY) 01/2014
1	Schizophrenia (Dementia Praecox) 12/2012
1	AIDS-Related Complex (ARC) 12/2012
1	Nerve Degeneration 09/2012
1	Nervous System Diseases (Neurological Disorders) 01/2012
1	Body Weight (Weight, Body) 01/2011
1	Cocaine-Related Disorders (Cocaine Addiction) 07/2009
1	Esophageal Neoplasms (Esophageal Cancer) 05/2009
1	Mitochondrial Diseases (Mitochondrial Disease) 04/2009

Drug/Important Bio-Agent (IBA)

15	Adenosine Triphosphate (ATP)IBA 10/2019 - 09/2005
8	InflammasomesIBA 01/2019 - 02/2014
6	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2019 - 04/2009
6	ORALIT (ORS)IBA 01/2014 - 04/2004
5	PotassiumIBA 10/2019 - 09/2005
5	Proteins (Proteins, Gene)FDA Link 09/2018 - 02/2005
5	N- (1- methylethyl)- 1,1,2- trimethylpropylamineIBA 09/2014 - 05/2005
5	RotenoneIBA 09/2008 - 05/2005
5	KATP ChannelsIBA 06/2006 - 05/2005
4	SynucleinsIBA 09/2018 - 01/2014
4	Neuroprotective AgentsIBA 01/2018 - 12/2007
4	Dopamine (Intropin)FDA LinkGeneric 01/2015 - 05/2005
4	Glutamic Acid (Glutamate)FDA Link 06/2006 - 02/2005
3	NLR ProteinsIBA 04/2016 - 02/2014
3	Folic Acid (Vitamin M)FDA LinkGeneric 07/2009 - 04/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2019 - 09/2012
2	Growth Hormone (Somatotropin)IBA 01/2015 - 03/2010
2	Thymidylate SynthaseIBA 01/2012 - 04/2004
2	AldehydesIBA 01/2010 - 05/2009
2	Cocaine (Cocaine HCl)IBA 07/2009 - 04/2006
2	Oxidoreductases (Dehydrogenase)IBA 07/2009 - 07/2009
2	Diazoxide (Hyperstat)FDA Link 09/2008 - 05/2005
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 04/2008 - 04/2004
2	Messenger RNA (mRNA)IBA 02/2006 - 02/2005
1	Complement System Proteins (Complement)IBA 01/2021
1	LipopolysaccharidesIBA 01/2021
1	astragaloside AIBA 04/2020
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 09/2018
1	QuinpiroleIBA 09/2018
1	MAP kinase kinase kinase 7IBA 09/2018
1	GTP-Binding Proteins (G-Protein)IBA 09/2018
1	CaspasesIBA 01/2017
1	Probenecid (Benemid)FDA LinkGeneric 01/2017
1	PyrrolidinesIBA 01/2017
1	Caspase 7IBA 01/2017
1	Adenosine Triphosphatases (ATPase)IBA 01/2016
1	InterferonsIBA 01/2016
1	ginkgolide BIBA 01/2016
1	Interleukin-4 (Interleukin 4)IBA 01/2016
1	Biological ProductsIBA 01/2016
1	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA 01/2016
1	Adenosine (Adenocard)FDA LinkGeneric 12/2015
1	Retinaldehyde (Retinal)IBA 01/2015
1	Caspase 1 (ICE Protease)IBA 09/2014
1	Antidepressive Agents (Antidepressants)IBA 09/2014
1	InterleukinsIBA 09/2014
1	Transcription Factor CHOPIBA 02/2014
1	Caspase 12IBA 02/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2014
1	Codon (Codons)IBA 01/2014
1	Tobacco Smoke Pollution (Passive Smoking)IBA 01/2013
1	Dizocilpine Maleate (Dizocilpine)IBA 12/2012
1	Uncoupling Protein 2IBA 09/2012
1	Serine (L-Serine)FDA Link 01/2012
1	3' Untranslated Regions (3' UTR)IBA 01/2012
1	5' Untranslated Regions (5' UTR)IBA 01/2012
1	Sucrose (Saccharose)IBA 01/2011
1	Connexin 43 (Connexin43)IBA 01/2011
1	5,10-methylenetetrahydrofolic acidIBA 07/2009
1	Aquaporin 4IBA 07/2009
1	mitochondrial K(ATP) channelIBA 04/2009
1	ProstaglandinsIBA 09/2008
1	Pinacidil (Pindac)FDA Link 09/2008

Therapy/Procedure

2	Therapeutics 09/2018 - 09/2014
1	Laparotomy 05/2016
1	Induced Abortion (Induced Abortions) 01/2012